DAMASCUS, Syria — A major hospital in rebel-held eastern Aleppo was put out of service after it was bombed Saturday in the latest medical facility attack in the embattled city, activists said.

Unidentified jets targeted the area where the hospital is located, killing at least one person and injuring an unspecified number of others.

Two barrel bombs hit the hospital, said Adham Sahloul, an official with the Syrian American Medical Society, a charity group that runs the hospital.

The hospital, code-named M10 for security reasons, is eastern Aleppo’s biggest hospital. It had been partially closed Wednesday after being hit with another hospital, Sahloul said.

The head of medical services in eastern Aleppo, Abu Jaafar Kaheel, said M10 was heavily damaged by direct hits in air raids Saturday.

Once Syria’s commercial hub, Aleppo has been divided between government forces in the west and rebels in the east since fighting erupted for control of the city in mid-2012.