FILE - In this Sept. 13, 2016 file photo provided by Modar Shekho, activists in Syria's besieged Aleppo protest against the United Nations for what they say is its failure to lift the siege off their rebel-held area, in Aleppo, Syria. Residents in the rebel-held districts of Aleppo have a reprieve from the incessant bombings by Syrian government warplanes and the promise of an end to the crippling siege that has left produce stalls bare. (Modar Shekho via AP, File)
FILE - In this Sept. 13, 2016 file photo provided by Modar Shekho, activists in Syria's besieged Aleppo protest against the United Nations for what they say is its failure to lift the siege off their rebel-held area, in Aleppo, Syria. Residents in the rebel-held districts of Aleppo have a reprieve from the incessant bombings by Syrian government warplanes and the promise of an end to the crippling siege that has left produce stalls bare. (Modar Shekho via AP, File) Credit: Modar Shekho

BEIRUT — Syria’s fragile cease-fire started to unravel on Sunday with the first aerial attacks on rebel-held neighborhoods of Aleppo and a southern village that killed at least eight people, violations that came as tensions between the American and Russian brokers of the deal worsened following a deadly U.S. strike on Syrian government forces.

The air raid by the U.S.-led coalition killed dozens of Syrian soldiers and led to a harsh verbal attack on Washington by Damascus and Moscow. The U.S. military says it may have unintentionally struck Syrian troops while carrying out a raid against the Islamic State group in eastern Syria on Saturday.

The seven-day cease-fire is supposed to end at midnight Sunday, according to a Syrian army statement issued last week. The U.S. and Russia have said that if it holds for seven days, it should be followed by the establishment of a Joint Implementation Center for both countries to coordinate the targeting of Islamic State and al-Qaida-linked militants.

Despite largely holding, the cease-fire has been repeatedly violated by both sides, and aid convoys have not reached besieged rebel-held neighborhoods of Aleppo, Syria’s largest city and one-time commercial center, which has been the center of violence in recent months. Aid delivery to Aleppo is part of the U.S.-Russia cease-fire deal.